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當前位置: 首頁> 產品中心> 信號轉導研究相關 > DNA損傷/修復 > (-)-Epigallocatechin Gallate (EGCG) (-)-表沒食子兒茶素沒食子酸酯
(-)-Epigallocatechin Gallate (EGCG) (-)-表沒食子兒茶素沒食子酸酯
目錄號 MZ3651-20MG 售價 238.00元
規格 20mg 運輸溫度 室溫運輸
其他名稱 Epigallocatechin gallate表沒食子兒茶素沒食子酸酯;Tea catechin兒茶素;NVP-XAA723;Teavigo; 保存溫度 -20°C干燥保存
CAS號 989-51-5 有效期 3年
應用 抗氧化劑 訂購數量
產品簡介:

(-)-Epigallocatechin Gallate (EGCG)


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產品信息                                                                                                            

產品名稱

產品編號

CAS NO.     

規格         

價格(元) 

(-)-Epigallocatechin Gallate (EGCG) (-)-表沒食子兒茶素沒食子酸酯 

MZ3651-20MG      

989-51-5

20mg

238

(-)-Epigallocatechin Gallate (EGCG) (-)-表沒食子兒茶素沒食子酸酯

MZ3651-100MG

989-51-5

100mg

598

(-)-Epigallocatechin Gallate (EGCG) (-)-表沒食子兒茶素沒食子酸酯

MZ3651-500MG

989-51-5

500mg

2188

【溫馨提示】:見我司的小分子化合物常見問題-懋康生物。 



產品描述

(-)-表沒食子兒茶素沒食子酸酯((-)-Epigallocatechin Gallate, EGCG),CAS NO. 989-51-5,是從綠茶中提取純化的一種成分,是兒茶素類化合物中最有效的活性成分,具有最強的抗氧化、抗癌、抗突變和抗血管生成活性,已被用于多種腫瘤包括肝癌、胃癌、皮膚癌、乳腺癌和結腸癌等的化學預防研究中,也對許多病毒包括HCV、HIV-1、HSV-1、HSV-2、腺病毒等有抑制作用。EGCG屬于一種天然的多酚黃酮類抗生素,能夠抑制端粒酶(telomerase)和DNA甲基轉移酶(DNA methyltransferase),阻止EGF受體和HER-2受體的激活,也能抑制脂肪酸合成酶和谷氨酸脫氫酶的活性。是一種β-分泌酶抑制劑(IC50=1.6μM),能抑制淀粉樣蛋白的組裝,抑制由蛋白如Aβ,α-突觸核蛋白和亨廷頓蛋白介導的淀粉樣纖維的形成。能抑制細胞生長和選擇性誘導A431和人胰腺癌細胞的凋亡。也是DNMT1抑制劑。


產品特性

1) CAS NO:989-51-5

2) 化學名:3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1- benzopyran-3-yl ester

3) 同義名:Epigallocatechin gallate表沒食子兒茶素沒食子酸酯;Tea catechin兒茶素;NVP-XAA723;Teavigo;

4) 分子式:C22H18O11

5)分子量:458.37 g/mol

6)純度:≥98% (HPLC)

7) 外觀:類白色至白色粉末

8)溶解性:溶于H2O(5 mg/ml),DMSO(20 mg/ml),無水乙醇(45 mg/ml)

9)化學結構:


保存與運輸方法

保存:-20oC干燥保存,3年有效。

運輸:常溫運輸。


使用方法【源自文獻,僅作參考】

文獻1,Rasheed NO et al.Nephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosis. Sci Rep. 2017 Jan 18;7:40617. PMID: 28098182

體內研究:

動物模型(Animal Model):Male Swiss albino mice weighing 25–30?g

藥物配制(Preparation):Teavigo, a highly purified extract containing 94% EGCG, dissolved in saline

注射劑量(Dosages):Mice were randomly divided into 4 groups 8 mice each except group 4 in which 15 mice were used: Group 1 received saline served as normal control. Group 2 received a single dose of STZ (150?mg/kg, i.p) used as diabetic control.Group 3 received EGCG (100?mg/kg, i.p) dissolved in saline for 4 days. Group 4 received STZ as in group 2 then the diabetic animals were injected after 48?hrs with EGCG as in group 3. After 48?hrs of STZ injection, animals with blood glucose level ≥200?mg/dl were selected as diabetic animals.

給藥途徑(Administration):Intraperitoneal (i.p.) injection


文獻2,Pan C et al.NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxid Med Cell Longev. 2017;2017:3172692. PMID: 28698767


體內研究:

動物模型(Animal Model):Eight-week-old male mice that was successfully induced as diabetic mice.

藥物配制(Preparation):EGCG dissolved in normal saline

注射劑量(Dosages):The diabetic mice and age-matched controls were treated daily by subcutaneously injected EGCG (100?mg/kg≥98%, dissolved in normal saline) or normal saline daily, for a total period of 24 weeks. Blood glucose was recorded on days 0, 28, 56, 84, 112, 140, and 168, after diabetes onset.

給藥途徑(Administration):Subcutaneous (s.c.) injection


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